Clinical Information

EPIFLO^®is a portable, 3 ounce oxygen generating unit which is designed to heal chronic skin wounds – wounds that have failed to heal for 60 days or more– by providing a continuous oxygen flow to the wound site 24/7. This therapy boosts metabolism and re-establishes tissue function. Collagen formation, granulation, angiogenesis and epithelialization are all oxygen dependent and oxygen driven. Some clinicians suggest that EPIFLO^® mimics the bloodstream in delivering oxygen to ischemic cells surrounding the chronic wound thus providing metabolic energy to allow normal wound healing to progress.

Case report studies are available on this web site and additional clinical data will be posted as available.

Clinical Poster Presentations
(CLICK TITLES TO VIEW CLINICAL POSTERS)

• Transdermal Continuous O2 Therapy in Treatment of Sickle Cell Ulcers
  —Presented at SAWC, Spring, 2012.
• Clinical Efficacy of Transdermal Continuous O2 Therapy in Patients With Diabetic Foot Ulcers
  —Presented at DFCON, Spring, 2012.
• Case Series: Transdermal Continuous O2 Therapy for Treatment of Complicated Foot Ulcers
  —Presented at DFCON, Spring, 2012.
• The Use of Transdermal Continuous Oxygen Therapy to Accelerate Wound Healing
  —Presented at SAWC, October, 2011
• Coumadin Necrosis Treatment with Transdermal Continuous Oxygen Therapy
  —Presented at SAWC, April, 2011
• The Use of Transdermal Continuous Oxygen Therapy as Adjunctive Treatment to Human Fibroplast Derived Dermal Substitute in Diabetic Foot Ulcers
  —Presented at DFCON, March, 2011
• The Use of Human Fibroblast-derived Dermal Substitute with Topical Oxygen in Vascular Compromised Wounds.
  —Published on EWMA website, 2010. (Click here for full Poster)
• Effect of Transdermal Continuous Oxygen Therapy on Four Wounds After Treatment with Negative Pressure Wound Therapy.
  —Presented at Diabetic Limb Salvage Conference, 2010.
• An Overview of Available Oxygen Therapies for Wound Care
  –Presented at the Desert Foot 2010 Conference.
• Successful Treatment of Recalcitrant Chronic Diabetic Foot Wounds with Transdermal Continuous Oxygen Therapy: Reviving the Dead Wound
  —Presented at the APMA Annual Conference, Toronto, ON July, 2009
• Transdermal Continuous Oxygen Therapy for Chronic Wound Management
  — Presented at the Canadian Association of Wound Care, London ON November 2007
• Transdermal Continuous Oxygen Therapy Heals Chronic Diabetic Ulcers After Other Advanced Therapies Failed. –Presented at SAWC, 2006
• Continuous Local Oxygen Delivery Promotes Wound Healing
  — Presented at the Symposium on Advanced Wound Care, Las Vegas, NV, 2003
• Amputation Date Cancelled Due to the Use of Transdermal, Sustained Oxygen Therapy in the Healing of a Diabetic Foot Ulcer with Osteomyelitis
  — Presented at the American Professional Wound Care Association, Philadelphia, PA, 2005

Publications (click on journal names to access publications)

• Ladizinsky, D.; Roe, D. “New Insights into Oxygen Therapy for Wound Healing.” J. Wounds, January, 2011.
• Coutts, P.; Sibbald, Gary. “Pilot Study to Evaluate the Use of Continuous Topical Oxygen Therapy in the Treatment of Chronic Wounds.” European Wound Management Association, October, 2010.
• Blackman, E; Moore, C; Hyatt, J; Railton R; Frye, C. “Topical Wound Oxygen Therapy in the Treatment of Severe Diabetic Foot Ulcers: A Prospective Controlled Study.” Ostomy and Wound Management. June, 2010.
• Schreml, S.; Szeimies, R.M.; Prantl, L.; Karrer, S.; Landthaler, M.; Babilas, P. “Oxygen in Acute and Chronic Wound Healing” British Journal of Dermatology. 2010;163(2):257-268. 2010
• Gordillo, G.; Sen, C. “Evidence-Based Recommendations or the Use of Topical Oxygen Therapy in the Treatment of Lower Extremity Wounds” Int. J. of Lower Extremity Wounds. June, 2009.
• Sen, C. “Wound Healing Essentials: Let There be Oxygen” J. Wound Repair and Regeneration, January, 2009.
• Hirsch, Fred; Berlin, Steven; Holtz, Aliza. “Transdermal Oxygen Delivery to Diabetic Wounds: A Study of 6 Cases.” August, 2008.
• Gordillo, G.; Sashwati, R.; Khanna, S.; Schlanger, R.; Khandelwal, S.; Phillips, G.; Sen, C. “Topical Oxygen Therapy Induces VEGF Expression and Improves Closure of Clinically Presented Chronic Wounds” Clin Exp Pharmacol Physiol. August, 2008.
• Davis, S.; Cazzaniga, A.; Ricotti, C. et al. “Topical Oxygen Emulsion: A Novel Wound Therapy” Arch. Dermatol, October, 2007.
• Said HK, Hijjawi J, Roy N, Mogford J, Mustoe T., “Transdermal sustained-delivery oxygen improves epithelial healing in a rabbit ear wound model.” Arch Surg. 2005 Oct;140(10):998-1004.
• Belda, F.; Aguilera, L.; Garcia de la Asuncion, J.; et al. “Supplemental perioperative Oxygen and the Risk of Surgical Wound Infection: A Randomized controlled Trial.” JAMA, October, 2005. (significant reduction in risk of wound infection.)
• Wilson, C. et al. “Transdermal Sustained Oxygen Therapy Promotes Healing of A Chronic Pressure Ulcer in A Patient With Osteomyelitis: A Case Report” J. Wound, Ostomy & Continence Nursing, 2005, 32(3S): Supplement 2: S6
• Scott GF, Reeves RE., “Topical Oxygen Alters Angiogenesis Related Growth Factor Expression in Chronic Diabetic Foot Ulcers.” Presented at: New Cardiovascular Horizons; Oct 1, 2005; Fort Worth, Texas.
• Heng, M.; Harker, J.; Bardakjian, V.; Ayvazian, H. “Enhanced Healing and Cost-Effectiveness of Low-Pressure Oxygen Therapy in Healing Necrotic Wounds: A Feasibility Study of Technology Transfer.” Ostomy Wound Management, March, 2000.